| AFC WEST END | V | | THE THREE GABLE SALMOMS | | |
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| BASSINGHAM BUGLE HORN FC | V | | WITHAM WANDERERS | | |
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| COLEBY FC | V | | AFC SAXILBY | | |
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| FISHTOFT | V | | STAGS HEAD FC | | |
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| HALF MOON INN FC | V | | SHAKESPEARE IMPS | | |
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| JUBILLEE FC (SPALDING) | V | | BROADLEY FC | | |
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| MARSHALLS FC (GAINSBOROUGH) | V | | PLOUGH STURTON | | |
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| METHERINGHAM FC | V | | NOBODY INN ATHLETIC | | |
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| PLOUGH SWINDERBY FC | V | | GEDNEY HILLBILLIES | | |
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| RUSTONS UNITED | V | | FVA JERUSALEM | | |
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| SLEAFORD AFC | V | | JOLLY SCOTCHMAN FC | | |
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| ST HELENS FC | V | | AFC BAILGATE | | |
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| SWANPOOL | V | | HYKEHAM TOWN TRFC | | |
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| WELTON SPORTS & SOCIAL FC | V | | WRAGBY FC | | |
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| WITHAM FC | V | | THE FERRYBOAT INN FC | | |
| TIES TO BE PLAYED ON SUNDAY 7TH NOVEMBER 2021 | | | | | |
| ROUND ONE | | | | | |
| AFC GOLDEN EAGLE | 2 | 3 | AFC SAXILBY | | |
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| AFC MOULTON SEAS END | 0 | 24 | RUSTONS UNITED | | |
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| BASSINGHAM BUGLE HORN FC | 6 | 2 | NEWELL'S FC | | |
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| BOTTLE & GLASS FC | 0 | 3 | WITHAM FC | | |
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| COLEBY FC | 3 | 0 | AFC COLSTERWORTH SPORTS & SOCIAL CLUB | | |
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| FISHTOFT FC | P | P | ACTIVE ARENA FC | HOME WIN | |
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| FVA JERUSALEM | P | P | MULBERRY FC | HOME WIN | |
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| HALF MOON INN FC | 4 | 2 | NORTH SCARLE FC | | |
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| HBW UNITED | 1 | 4 | SWANPOOL FC | | |
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| HYKEHAM MEMORIAL FC | 0 | 1 | ROPSLEY FC | | |
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| HYKEHAM TOWN TRFC | 5 | 0 | RECRUITING SERGEANT FC | | |
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| POTTERHANWORTH FC | 3 | 4 | SHAKESPEARE IMPS FC | | |
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| QUEEN ATHLETIC | 0 | 2 | THE THREE GABLE SALMONS FC | | |
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| SAXILBY ATHLETIC | 2 | 4 | PLOUGH SWINDERBY FC | | |
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| SOUTH HOLLAND UNITED | 1 | 2 | SLEAFORD AFC | | |
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| ST HELENS FC | 2 | 0 | LINCOLNSHIRE POACHER FC | | |
| STAGS HEAD FC | 3 | 1 | AFC BEEHIVE | | |
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| THE FERRYBOAT INN FC | 1 | 0 | RAILWAY INN UNITED | | |
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| WADDINGTON UNITED | 0 | 4 | NOBODY INN ATHLETIC FC | | |
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| WELTON SPORTS & SOCIAL FC | 3 | 2 | MORNING STAR FC | | |
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| WRAGBY FC | H | H | NATIONS UNITED | HOME WIN | |
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| TIES PLAYED ON SUNDAY 3RD OCTOBER 2021 | | | | | |
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| BYES (AUTOMATICALLY PROGRESSING TO ROUND TWO) | | | | | |
| AFC BAILGATE | | | | | |
| AFC WEST END | | | | | |
| BROADLEY FC | | | | | |
| JOLLY SCOTCHMAN FC | | | | | |
| METHERINGHAM FC | | | | | |
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